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Each episode of Sign of the Times centers on a particular cultural icon or topic and dissects the relevant astrological angles. The structure of each episode is split into three parts, with the first part focusing on the birth chart of the episode's central figure, the second part considering their relationships or broader cultural significance from an astrological viewpoint, and the third part forecasting their future using astrological transits. It is an "astrology hotline" where audiences can submit their questions and have the most liked ones answered on the show.